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Regenerative Ophthalmology Research

Regenerative ophthalmology is an emerging field studying whether cells, cell-derived signals and engineered tissues could one day replace, protect or support damaged eye tissue. Most of it is preclinical or early-phase. These hubs explain each approach and link to the conditions where it has been studied.

Stem Cell Research

An overview of the stem and progenitor cell types researchers study in vision science — what they are, how they differ, and how far the research has progressed.

Stargardt DiseaseGlaucoma
Mesenchymal Stromal/Stem Cells (MSCs)

What MSCs are, where they come from, and why researchers study their signaling and immune-modulating activity in the eye.

Age-Related Macular DegenerationRetinitis Pigmentosa & Inherited Retinal DiseasesDiabetic Retinopathy & Diabetic Macular EdemaGlaucomaOptic Nerve Damage & Optic NeuropathyLimbal Stem Cell Deficiency & Corneal DamageDry Eye DiseaseUveitis & Ocular Inflammation
Induced Pluripotent Stem Cells (iPSCs)

Adult cells reprogrammed to a pluripotent state, used in research to derive retinal cells and to model inherited eye disease.

Age-Related Macular DegenerationRetinitis Pigmentosa & Inherited Retinal Diseases
Stem-Cell-Derived RPE Cells

Retinal pigment epithelial cells grown from pluripotent stem cells — one of the most studied cell-replacement approaches in retinal research.

Age-Related Macular DegenerationStargardt Disease
Retinal Progenitor Cells

Immature retinal cells studied for their potential to support or replace photoreceptors in degenerative retinal disease.

Retinitis Pigmentosa & Inherited Retinal Diseases
Limbal Stem Cells

The stem cells that maintain the corneal surface; the basis of established surgical approaches for limbal stem cell deficiency.

Limbal Stem Cell Deficiency & Corneal Damage
Extracellular Vesicles

Membrane-bound particles released by cells that carry proteins, lipids and RNA — studied as messengers in cell-to-cell signaling.

Age-Related Macular DegenerationDiabetic Retinopathy & Diabetic Macular EdemaGlaucomaOptic Nerve Damage & Optic NeuropathyDry Eye Disease
Exosomes

A subtype of extracellular vesicle. Why the terminology matters, and why an exosome should not automatically be described as a treatment.

Wharton’s Jelly

The gel-like tissue of the umbilical cord, a source of MSCs and extracellular matrix studied in the laboratory.

Regenerative Ophthalmology Research | EyeCyte